Brighton will be without both Lewis Dunk and Neal Maupay as the pair were shown red cards in the defeat at Wolves last time out and serve a ban this weekend.
Solly March (knee) and Tariq Lamptey (hamstring) are also out with doubts over Davy Propper (ankle) and Joel Veltman (calf) – although Adam Lallana should be fit following his own calf issue.
There could be a chance for Alexis Mac Allister to shine while Danny Welbeck is poised to lead the line up front in Maupay's absence.
Scroll down and click through to see our predicted line-up against West Ham
1. Rob Sanchez
The 23-year-old Spaniard has impressed for Brighton this season and will take his place between the sticks once more to face West Ham
2. Ben White
Really enjoyed Ben White's performances this season and the academy graduate will likely line-up on the right of a three man defence
3. Adam Webster
Will likely take the captain's arm band in Lewis Dunk's absence and will be at the heart of the defence. Graham Potter said, "He is one of those people that steps into that space that Dunky leaves and the captaincy because he does lead well. He has respect in the dressing room."
4. Dan Burn
Has played in numerous roles this season and will likely drop back on to the left side of the defence for this one